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Schematic illustration of the in vivo therapy strategy for acetaminophen-induced acute liver injury using ROS-scavenging <t>nanoparticles</t> loaded with Tec. The intravenously administered PBHB@Tec nanoparticles, with an engineered polymeric structure, preferentially accumulate in damaged hepatocytes. Upon sensing elevated ROS levels in the injured liver, HBPAK collaborates with the released Tec to alleviate ER stress and mitochondrial dysfunction, thereby suppressing hepatocyte apoptosis and promoting liver repair.
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Schematic illustration of the in vivo therapy strategy for acetaminophen-induced acute liver injury using ROS-scavenging nanoparticles loaded with Tec. The intravenously administered PBHB@Tec nanoparticles, with an engineered polymeric structure, preferentially accumulate in damaged hepatocytes. Upon sensing elevated ROS levels in the injured liver, HBPAK collaborates with the released Tec to alleviate ER stress and mitochondrial dysfunction, thereby suppressing hepatocyte apoptosis and promoting liver repair.

Journal: Bioactive Materials

Article Title: ROS-scavenging nanoparticles loaded with tectorigenin protect against acetaminophen-induced hepatotoxicity by interrupting the calcium/ROS-mediated pathogenic endoplasmic reticulum–Mitochondrial signaling cascade

doi: 10.1016/j.bioactmat.2025.12.016

Figure Lengend Snippet: Schematic illustration of the in vivo therapy strategy for acetaminophen-induced acute liver injury using ROS-scavenging nanoparticles loaded with Tec. The intravenously administered PBHB@Tec nanoparticles, with an engineered polymeric structure, preferentially accumulate in damaged hepatocytes. Upon sensing elevated ROS levels in the injured liver, HBPAK collaborates with the released Tec to alleviate ER stress and mitochondrial dysfunction, thereby suppressing hepatocyte apoptosis and promoting liver repair.

Article Snippet: Nanoparticle morphology was examined by TEM (HT7700, Hitachi), and the elemental composition was determined by XPS (Axis Supra+, Kratos).

Techniques: In Vivo

Characterization and ROS-responsiveness of PBHB@Tec. (a) Schematic illustration of the preparation of PBHB@Tec nanoparticles and their ROS-triggered degradation as well as Tec release. (b) DLS analysis showing the size distribution of PBHB and PBHB@Tec nanoparticles. (c) Zeta potential measurements of PBHB and PBHB@Tec. (d) TEM images of PBHB and PBHB@Tec nanoparticles. Scale bar: 500 nm. (e) XPS spectra indicating the chemical composition of PBHB@Tec. (f, g) In vitro ABTS radical scavenging activity and H 2 O 2 clearance ability of PBHB and PBHB@Tec at various concentrations. (h) Cumulative release profiles of Tec from PBHB@Tec nanoparticles in the absence and presence of H 2 O 2 . (i) TEM images of PB, PB incubated with H 2 O 2 , PBHB@Tec, and PBHB@Tec incubated with H 2 O 2 to visualize nanoparticle stability and ROS-triggered degradation. Scale bar: 500 nm. Data are expressed as mean ± SD (n = 3).

Journal: Bioactive Materials

Article Title: ROS-scavenging nanoparticles loaded with tectorigenin protect against acetaminophen-induced hepatotoxicity by interrupting the calcium/ROS-mediated pathogenic endoplasmic reticulum–Mitochondrial signaling cascade

doi: 10.1016/j.bioactmat.2025.12.016

Figure Lengend Snippet: Characterization and ROS-responsiveness of PBHB@Tec. (a) Schematic illustration of the preparation of PBHB@Tec nanoparticles and their ROS-triggered degradation as well as Tec release. (b) DLS analysis showing the size distribution of PBHB and PBHB@Tec nanoparticles. (c) Zeta potential measurements of PBHB and PBHB@Tec. (d) TEM images of PBHB and PBHB@Tec nanoparticles. Scale bar: 500 nm. (e) XPS spectra indicating the chemical composition of PBHB@Tec. (f, g) In vitro ABTS radical scavenging activity and H 2 O 2 clearance ability of PBHB and PBHB@Tec at various concentrations. (h) Cumulative release profiles of Tec from PBHB@Tec nanoparticles in the absence and presence of H 2 O 2 . (i) TEM images of PB, PB incubated with H 2 O 2 , PBHB@Tec, and PBHB@Tec incubated with H 2 O 2 to visualize nanoparticle stability and ROS-triggered degradation. Scale bar: 500 nm. Data are expressed as mean ± SD (n = 3).

Article Snippet: Nanoparticle morphology was examined by TEM (HT7700, Hitachi), and the elemental composition was determined by XPS (Axis Supra+, Kratos).

Techniques: Zeta Potential Analyzer, In Vitro, Activity Assay, Incubation